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Initiate a new buy or access check status and benefits for clinical genomics or newborn screening services.

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The antibody is from purified rabbit serum by affinity purification by using sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.

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Overexpression of this gene has been noticed in lots of tumors, which results in chromosome instability, and so may well lead to tumorigenesis. This protein was identified to associate with, and become associated with, the phosphorylation of NPAT protein (nuclear protein mapped towards the ATM locus), which participates in mobile-cycle regulated histone gene expression and plays a significant position in marketing cell-cycle development while in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinctive isoforms, have already been explained. Two added splice variants had been claimed but thorough nucleotide sequence info just isn't nonetheless obtainable.

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Blocking peptides are peptides that bind specially to the focus on antibody and block antibody binding. These peptide ordinarily consists of the epitope identified by the antibody.

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This guideline outlines further more doable optimization of cellular and immunoassay parameters to make sure the very best effects are...

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This information outlines even more doable optimization of mobile and immunoassay parameters to guarantee the very best effects are...

Antibodies more info sure to the blocking peptide no more bind to your epitope to the focus on protein. By evaluating the staining through the blocked antibody as opposed to the antibody on your own, one can see which staining is specific.

Concentrate on Information and facts Cyclin E belongs into the remarkably conserved cyclin relatives, whose customers are characterized by a dramatic periodicity in protein abundance in the mobile cycle. Cyclins operate as regulators of CDK kinases. Various cyclins show unique expression and degradation patterns which add to your temporal coordination of every mitotic occasion. Cyclin E sorts a fancy with and features being a regulatory subunit of CDK2, whose activity is required for mobile cycle G1/S changeover. This protein accumulates in the G1-S section boundary and is degraded as cells development via S section.

The measurement of protein phosphorylation is a useful gizmo for measuring the modulation of receptor activation by the two antibodies...

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